This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Function:
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.
Subcellular Location:
Cytoplasm; cell cortex. Cytoplasm; perinuclear region. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.
Similarity:
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Contains 4 IQ domains.
Contains 1 myosin motor domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-associating domain.
Contains 1 Rho-GAP domain.
SWISS:
Q13459
Gene ID:
4650
Database links:
Entrez Gene: 4650 Human
Entrez Gene: 17925 Mouse
Omim: 602129 Human
SwissProt: Q13459 Human
SwissProt: Q9QY06 Mouse
SwissProt: Q63358 Rat
Unigene: 159629 Human
Unigene: 33779 Mouse
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