PROSC is a 275 amino acid ubiquitously expressed enzyme that is highly conserved from bacteria to mammals. The gene encoding PROSC is cotranscribed with proline sythetase. PROSC requires the cofactor pyridoxal phosphate, the active form of vitamin B6 that acts in all transamination reactions. The PROSC gene maps to human chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the UPF0001 family.
SWISS:
O94903
Gene ID:
11212
Database links:
Entrez Gene: 11212 Human
Entrez Gene: 114863 Mouse
Entrez Gene: 306544 Rat
Omim: 604436 Human
SwissProt: O94903 Human
SwissProt: Q9Z2Y8 Mouse
Unigene: 304792 Human
Unigene: 608177 Human
Unigene: 277501 Mouse
Unigene: 485663 Mouse
Unigene: 228631 Rat
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