Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Function:
This protein binds to a specific region on the 26S rRNA.
Post-translational modifications:
N-terminus is methylated by METTL11A/NTM1.
Similarity:
Belongs to the ribosomal protein L23P family.
SWISS:
P62750
Gene ID:
6147
Database links:
Entrez Gene: 6147 Human
Entrez Gene: 417574 Chicken
Entrez Gene: 507168 Cow
Entrez Gene: 100043755 Mouse
Entrez Gene: 268449 Mouse
Entrez Gene: 72572 Rat
Entrez Gene: 447121 Xenopus laevis
Entrez Gene: 448689 Xenopus tropicalis
GenBank: NP_000975.2 Human
Omim: 602326 Human
SwissProt: Q24JY1 Cow
SwissProt: P62750 Human
SwissProt: P62751 Mouse
SwissProt: P62752 Rat
Unigene: 419463 Human
Unigene: 22723 Mouse
Unigene: 304790 Mouse
Unigene: 352675 Mouse
Unigene: 6018 Rat
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