NEDL2 is a 1,572 amino acid cytoplasmic protein that is involved in protein modification and ubiquitination and exists as two alternatively spliced isoforms. NEDL2 acts as an E3 ubiquitin-protein ligase that enhances p73 transcription activation, ubiquitination and stabilization, and is highly expressed in adult heart, lung and brain. Containing one C2 domain, two WW domains and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain, NEDL2 is encoded by a gene that maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in adult brain, lung and heart.
Similarity:
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains.
SWISS:
Q9P2P5
Gene ID:
57520
Database links:
Entrez Gene: 57520 Human
Entrez Gene: 329152 Mouse
Entrez Gene: 100155879 Pig
Entrez Gene: 316395 Rat
SwissProt: Q9P2P5 Human
SwissProt: Q6I6G8 Mouse
Unigene: 654742 Human
Unigene: 132150 Mouse
Unigene: 447527 Mouse
Unigene: 198842 Rat
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