This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the FPG family.
SWISS:
Q96FI4
Gene ID:
79661
Database links:
Entrez Gene: 79661 Human
Entrez Gene: 72774 Mouse
Omim: 608844 Human
SwissProt: Q96FI4 Human
SwissProt: Q8K4Q6 Mouse
Unigene: 512732 Human
Unigene: 35749 Mouse
Unigene: 87637 Mouse
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