The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
Subunit:
The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
Post-translational modifications:
Sumoylated.
Similarity:
Belongs to the RRM NELF-E family.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
P18615
Gene ID:
7936
Database links:
Entrez Gene: 7936 Human
Omim: 154040 Human
SwissProt: P18615 Human
Unigene: 423935 Human
|
|
