Nephronectin is a 565 amino acid member of the nephronectin family that contains five EGF-like domains and an Arg-Gly-Asp (RGD) cell binding motif, as well as a meprin, A5 protein and receptor protein-tyrosine phosphatase µ (MAM) domain. Expressed in kidney, thyroid and parathyroid glands, developing bone, tooth germ, skeletal and smooth muscle, brain and skin, POEM is involved in the development and function of bone, muscle and kidney tissue. The most established function of POEM is as a ligand to the receptor Integrin å8/∫1. Highly expressed in the nephritic cord, Integrin å8/∫1 plays a critical role in kidney morphogenesis and development. The POEM-Integrin å8∫1 complex regulates the expression of GDNF, another protein that affects kidney development, specifically by regulating the growth of the uretic bud. There are two named isoforms of POEM, both of which form homodimers or homotrimers.
Function:
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
Subcellular Location:
Secreted > extracellular space > extracellular matrix. Trapped on the cell surface or in the extracellular matrix.
Tissue Specificity:
Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
Similarity:
Belongs to the nephronectin family.
Contains 5 EGF-like domains.
Contains 1 MAM domain.
SWISS:
Q6UXI9
Gene ID:
255743
Database links:
Entrez Gene: 255743 Human
Entrez Gene: 114249 Mouse
Omim: 610306 Human
SwissProt: Q6UXI9 Human
SwissProt: Q91V88 Mouse
Unigene: 518921 Human
Unigene: 279310 Mouse
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