Neurexophilin-1-3 are secreted proteins that are thought to function as signaling molecules which specifically bind to target proteins, such as neurexin I Alpha(a protein that promotes adhesion between dendrites and axons), and are essential for proper neurotransmitter release. While Neurexophilin-1 is located primarily in spleen tissue, Neurexophilin-2 is expressed primarily in kidney and both Neurexophilin-2 and Neurexophilin-3 are highly expressed in brain. Defects in the gene encoding Neurexophilin-1 may be associated with schizophrenia, a mental disorder characterized by an abnormal perception of reality.
Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.
Subcellular Location:
Secreted.
Tissue Specificity:
Highest level in brain.
Post-translational modifications:
May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
Similarity:
Belongs to the neurexophilin family.
SWISS:
O95157
Gene ID:
11248
Database links:
Entrez Gene: 11248 Human
Entrez Gene: 104079 Mouse
Entrez Gene: 59315 Rat
Omim: 604636 Human
SwissProt: O95157 Human
SwissProt: Q91VX5 Mouse
SwissProt: Q9Z2N5 Rat
Unigene: 55069 Human
Unigene: 22970 Mouse
Unigene: 19736 Rat
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