Rabbit Anti-Neurochondrin antibody

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AU042419; KIAA0607; M-Sema F-associating protein of 75 kDa; MGC93259; MMS10-AE; Ms10ae; NCDN; NCDN-1; Neurochondrin 1; Norbin; OTTHUMP00000065369; OTTHUMP00000065370; OTTHUMP00000065371; Sfap75.

Cat:

SL19517R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Neurochondrin:2-100/729

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

Function:
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling By similarity. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

Subcellular Location:
Cytoplasm. Cell projection, dendrite.

Tissue Specificity:
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.

Similarity:
Interacts with SEMA4C, DIAPH1 (via FH3 domain) and GRM5 By similarity. Interacts with MCHR1.

SWISS:
Q9UBB6

Gene ID:
23154

Database links:

Entrez Gene: 23154 Human

Entrez Gene: 505994 Cow

Entrez Gene: 26562 Mouse

Entrez Gene: 89791 Rat

Omim: 608458 Human

SwissProt: Q2KJ97 Cow

SwissProt: Q9UBB6 Human

SwissProt: Q91YH7 Mouse

SwissProt: O35095 Rat

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