NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production.
Subcellular Location:
Nucleus. Cytoplasm. TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Post-translational modifications:
Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
Similarity:
Contains 1 ubiquitin-like domain.
SWISS:
Q8NCF5
Gene ID:
84901
Database links:
Entrez Gene: 84901 Human
Entrez Gene: 3620 Mouse
Entrez Gene: 308983 Rat
Omim: 614525 Human
SwissProt: Q9GLZ9 Cynomolgus Monkey
SwissProt: Q8NCF5 Human
SwissProt: O09130 Mouse
SwissProt: Q6AYG7 Rat
Unigene: 513470 Human
Unigene: 1389 Mouse
Unigene: 101030 Rat
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