Rabbit Anti-NFKBIL2 antibody

Home > Product > Antibody > Rabbit Anti-NFKBIL2 antibody

I kappa B related protein; I-kappa-B-related protein; IkappaBR; IKBR; Inhibitor of kappa B related protein; Inhibitor of kappa B-related protein; MMS22L-interacting protein; MMS22L-interacting protein, NFBIL2/TONSL; NF kappa B inhibitor like protein 2; NF

Cat:

SL19225R

Species Reactivity：

(predicted: Mouse,Rat,Dog,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human NFKBIL2:181-280/301

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

Function:
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.

Subcellular Location:
Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.

Tissue Specificity:
Expressed in heart, skeletal muscle and tracheal epithelial cells.

Similarity:
Belongs to the Tonsoku family.
Contains 3 ANK repeats.
Contains 7 LRR (leucine-rich) repeats.
Contains 8 TPR repeats.

SWISS:
Q96HA7

Gene ID:
4796

Database links:

Entrez Gene: 505102 Cow

Entrez Gene: 475127 Dog

Entrez Gene: 4796 Human

Entrez Gene: 72749 Mouse

Entrez Gene: 366953 Rat

Omim: 604546 Human

SwissProt: Q0P5G1 Cow

SwissProt: Q96HA7 Human

SwissProt: Q6NZL6 Mouse

SwissProt: D4A615 Rat

Unigene: 675285 Human

Unigene: 358749 Mouse

Unigene: 19092 Rat

Product Feedback Wall