DNA-binding protein R kappa-B, is a nuclear protein that binds to the DNA consensus sequence 5'-GGGGAATCTCSLC3' of NF kappa B. Binding of NFR kappa B is thought to regulate IL-2R alpha (interleukin-2 receptor alpha-chain) gene expression, a critical step in T-cell activation. NFR kappa B exists as 3 isoforms due to alternative splicing and is expressed primarily in the brain, liver, spleen, testis and thymus NFR kappa B gene expression is amplified in acute myeloid leukemia, suggesting a possible role in carcinogenesis.
Function:
Binds to the DNA consensus sequence 5'-GGGGAATCTCSLC3'.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
Subcellular Location:
Nuclear
Tissue Specificity:
Expressed in thymus, brain, testes, spleen and liver.
SWISS:
Q6P4R8
Gene ID:
4798
Database links:
Entrez Gene: 419727 Chicken
Entrez Gene: 419730 Chicken
Entrez Gene: 4798 Human
Entrez Gene: 235134 Mouse
Entrez Gene: 315523 Rat
Omim: 112813 Human
SwissProt: Q6P4R8 Human
SwissProt: Q6PIJ4 Mouse
Unigene: 530539 Human
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