Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Function:
Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.
Subcellular Location:
Cytoplasm. Nucleus and Mitochondrion.
Tissue Specificity:
Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas.
Similarity:
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
SWISS:
Q9Y697
Gene ID:
9054
Database links:
Entrez Gene: 9054 Human
Entrez Gene: 3641 Mouse
Entrez Gene: 84594 Rat
Omim: 603485 Human
SwissProt: Q9Y697 Human
SwissProt: Q9Z1J3 Mouse
SwissProt: Q99P39 Rat
Unigene: 194692 Human
Unigene: 28724 Mouse
Unigene: 3151 Rat
|
|
