The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the NFYA/HAP2 subunit family.
SWISS:
P23511
Gene ID:
960
Database links:
Entrez Gene: 960 Human
Entrez Gene: 539584 Cow
Entrez Gene: 3644 Mouse
Entrez Gene: 29508 Rat
Omim: 189903 Human
SwissProt: Q5E9S2 Cow
SwissProt: P23511 Human
SwissProt: P23708 Mouse
SwissProt: P18576 Rat
Unigene: 10441 Human
Unigene: 4929 Mouse
Unigene: 10747 Rat
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