This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Function:
Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the NFYC/HAP5 subunit family.
SWISS:
Q13952
Gene ID:
962
Database links:
Entrez Gene: 419642 Chicken
Entrez Gene: 534003 Cow
Entrez Gene: 475312 Dog
Entrez Gene: 100715361 Guinea pig
Entrez Gene: 100053895 Horse
Entrez Gene: 962 Human
Entrez Gene: 3646 Mouse
Entrez Gene: 25337 Rat
Entrez Gene: 323445 Zebrafish
Omim: 605344 Human
SwissProt: Q5E9X1 Cow
SwissProt: Q13952 Human
SwissProt: P70353 Mouse
SwissProt: Q62725 Rat
Unigene: 713051 Human
Unigene: 435590 Mouse
Unigene: 477613 Mouse
Unigene: 1457 Rat
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