Rabbit Anti-Somatostatin Receptor 2 antibody

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somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN.

Cat:

SL2206R

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human Somatostatin Receptor 2:51-150/369<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively.

Function:
Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.

Subunit:
The SLCterminus interacts with SHANK1 PDZ domain.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P30874

Gene ID:
6752

Database links:

Entrez Gene: 6752 Human

Entrez Gene: 20606 Mouse

Entrez Gene: 54305 Rat

Omim: 182452 Human

SwissProt: P30874 Human

SwissProt: P30875 Mouse

SwissProt: P30136 Rat

Unigene: 514451 Human

Unigene: 454968 Mouse

Unigene: 202974 Rat

Unigene: 9929 Rat

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