The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
Tissue Specificity:
High expression level is found in brain, testis, liver and kidney. Weak expression in spleen, leukocytes, small intestine and colon
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
SWISS:
P30532
Gene ID:
228
Database links:
Entrez Gene: 386577 Chicken
Entrez Gene: 619369 Chimpanzee
Entrez Gene: 282177 Cow
Entrez Gene: 228 Human
Omim: 118505 Human
SwissProt: P26152 Chicken
SwissProt: Q5IS51 Chimpanzee
SwissProt: Q8SPU7 Cow
SwissProt: P30532 Human
Unigene: 1614 Human
Unigene: 719767 Human
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