This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Function:
Component of a putative tumor-recognition complex. Involved in the function of NK cells.
Subunit:
Contains 1 PPIase cyclophilin-type domain.
Subcellular Location:
Membrane. Attached to the membrane via its N-terminus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
SWISS:
P30414
Gene ID:
4820
Database links:
Entrez Gene: 4820 Human
Omim: 161565 Human
SwissProt: P30414 Human
Unigene: 529509 Human
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