This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Function:
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
Subcellular Location:
Cell membrane. Cytoplasm. Cytoplasmic vesicle.
Tissue Specificity:
Expressed in kidney, lung, pancreas and spleen.
Post-translational modifications:
Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.
Similarity:
Belongs to the NKD family.
Contains 1 EF-hand domain.
SWISS:
Q969F2
Gene ID:
85409
Database links:
Entrez Gene: 85409 Human
Omim: 607852 Human
SwissProt: Q969F2 Human
Unigene: 48951 Human
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