Rabbit Anti-NKF3 kinase family member antibody

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FLJ21140; FLJ34483; KIAA2002; NKF3 kinase family member; PEAK1; PEAK1_HUMAN; pseudopodium enriched atypical kinase; Pseudopodium-enriched atypical kinase 1; SGK269; Sugen kinase 269; Tyrosine-protein kinase SgK269.

Cat:

SL19263R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human NKF3 kinase family member:661-760/1746

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]

Function:
Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Colocalizes with F-actin in serum-rich medium. Actin colocalization is reduced during serum starvation.

Post-translational modifications:
Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation. Autophosphorylated in vitro.

Similarity:
Belongs to the protein kinase superfamily.
Contains 1 protein kinase domain.

SWISS:
Q9H792

Gene ID:
79834

Database links:

Entrez Gene: 79834 Human

Omim: 614248 Human

SwissProt: Q9H792 Human

Unigene: 9587 Human

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