In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest levels of expression in adult testis; modest levels in fetal kidney and brain.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
Q9NZV7
Gene ID:
23619
Database links:
Entrez Gene: 23619 Human
SwissProt: Q9NZV7 Human
Unigene: 726173 Human
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