Rabbit Anti-Nkx3.1 antibody

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BAPX 2; BAPX2; Homeobox protein NK-3 homolog A; Homeobox protein Nkx 3.1; Homeobox protein Nkx-3.1; Homeobox protein Nkx3.1; NK homeobox (Drosophila) family 3 A; NK homeobox family 3 A; NK homeobox, family 3, member A; NK3 homeobox 1; NK3 transc

Cat:

SL19277R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Nkx3.1:101-200/234

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

Function:
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PSLC3 prostate cancer cells.

Subunit:
Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in the prostate and, at a lower level, in the testis.

Post-translational modifications:
Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.

Similarity:
Belongs to the NK-3 homeobox family.
Contains 1 homeobox DNA-binding domain.

SWISS:
Q91961

Gene ID:
4824

Database links:

Entrez Gene: 4824 Human

Entrez Gene: 3695 Mouse

Entrez Gene: 305999 Rat

Omim: 602041 Human

SwissProt: Q91961 Human

SwissProt: P97436 Mouse

Unigene: 55999 Human

Unigene: 3520 Mouse

Unigene: 43468 Rat

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