This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Function:
May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Detected in peripheral blood mononuclear cells.
Similarity:
Belongs to the NLRP family.
Contains 16 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
SWISS:
Q7RTR2
Gene ID:
197358
Database links:
Entrez Gene: 197358 Human
Entrez Gene: 268857 Mouse
Entrez Gene: 287070 Rat
SwissProt: Q7RTR2 Human
SwissProt: Q5DU56 Mouse
Unigene: 2061102 Human
Unigene: 728268 Human
Unigene: 215994 Mouse
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