NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a SLCterminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a SLCterminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Function:
Involved in inflammation.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 5 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
SWISS:
Q86W28
Gene ID:
126205
Database links:
Entrez Gene: 126205 Human
Omim: 609659 Human
SwissProt: Q86W28 Human
Unigene: 446925 Human
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