N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
Similarity:
Belongs to the NNMT/PNMT/TEMT family.
SWISS:
P40261
Gene ID:
4837
Database links:
Entrez Gene: 4837 Human
Entrez Gene: 18113 Mouse
Entrez Gene: 100144485 Pig
Entrez Gene: 300691 Rat
Omim: 600008 Human
SwissProt: P40261 Human
SwissProt: O55239 Mouse
SwissProt: Q06AV1 Pig
Unigene: 503911 Human
Unigene: 623245 Human
Unigene: 458542 Mouse
Unigene: 8362 Mouse
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