The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
NOL6 is a nucleolar RNA associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts.
Subcellular Location:
Nucleus; nucleolus. Localizes to condensed chromosomes in mitosis.
SWISS:
Q9H6R4
Gene ID:
65083
Database links:
Entrez Gene: 65083 Human
Entrez Gene: 230082 Mouse
SwissProt: Q9H6R4 Human
SwissProt: Q8R5K4 Mouse
Unigene: 493709 Human
|
|
