Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.
Subcellular Location:
Nucleus > nucleolus. Cytoplasm. Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.
Post-translational modifications:
Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence suggesting that CDK1 kinase phosphorylates p130 at the M-phase.
Similarity:
Contains 1 LisH domain.
SWISS:
Q14978
Gene ID:
9221
Database links:
Entrez Gene: 9221 Human
Entrez Gene: 609496 Dog
Entrez Gene: 70769 Mouse
Entrez Gene: 64896 Rat
Omim: 602394 Human
SwissProt: Q14978 Human
SwissProt: P41777 Rat
Unigene: 523238 Human
Unigene: 402190 Mouse
Unigene: 9517 Rat
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