Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 homeobox DNA-binding domain.
SWISS:
A8MTQ0
Gene ID:
38822
Database links:
Entrez Gene: 384452 Mouse
SwissProt: Q5TIS6 Mouse
Unigene: 347883 Mouse
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