NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
Function:
Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNT.
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
SWISS:
Q8IUM7
Gene ID:
266743
Database links:
Entrez Gene: 266743 Human
Entrez Gene: 225872 Mouse
Entrez Gene: 266734 Rat
Entrez Gene: 74816 Zebrafish
Omim: 608554 Human
SwissProt: Q8IUM7 Human
SwissProt: Q8BGD7 Mouse
SwissProt: Q8CJH6 Rat
SwissProt: Q1ECW2 Zebrafish
Unigene: 256036 Human
Unigene: 287867 Mouse
Unigene: 86654 Rat
Unigene: 81110 Zebrafish
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