The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular Location:
Secreted and Cell membrane. Does not seem to be active.
Post-translational modifications:
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage.
Similarity:
Belongs to the neuregulin family.
Contains 1 EGF-like domain.
SWISS:
Q8WWG1
Gene ID:
145957
Database links:
Entrez Gene: 145957 Human
Entrez Gene: 83961 Mouse
Entrez Gene: 690919 Rat
Omim: 610894 Human
SwissProt: Q8WWG1 Human
SwissProt: Q9WTX4 Mouse
Unigene: 732438 Human
Unigene: 443874 Mouse
Unigene: 120491 Rat
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