NRIP2 is a 281 amino acid nuclear protein that down-regulates transcriptional activation by nuclear receptors such as ROR∫. The gene encoding NRIP2 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
Down-regulates transcriptional activation by nuclear receptors such as NR1F2.
Subunit:
Interacts with NR1F2, RARA and THRB in a ligand-dependent manner.
Subcellular Location:
Nucleus.
SWISS:
Q9BQI9
Gene ID:
83714
Database links:
Entrez Gene: 83714 Human
Entrez Gene: 60345 Mouse
SwissProt: Q9BQI9 Human
SwissProt: Q9JHR9 Mouse
Unigene: 530816 Human
Unigene: 269883 Mouse
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