Neurensin-2 is a 204 amino acid multi-pass membrane protein belonging to the VMP family that may be involved in the transport and maintenance of vesicles. Expressed in brain, Neurensin-2 localizes to cell bodies of hippocampus, diagonal band, amygdaloid nucleus, and habenula nucleus, and is a potential tumor suppressor gene and candidate biomarker for long-term survival in patients with hepatocellular carcinoma (HCC). The gene encoding Neurensin-2 maps to human chromosome 20, which comprises approximately 2% of the human genome, contains nearly 63 million bases and encodes over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
Function:
May play a role in maintenance and/or transport of vesicles.
Subcellular Location:
Membrane.
Similarity:
Belongs to the VMP family.
SWISS:
Q9GZP1
Gene ID:
80023
Database links:
Entrez Gene: 80023 Human
Omim: 610666 Human
SwissProt: Q9GZP1 Human
Unigene: 416024 Human
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