SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 1157250]).[supplied by OMIM, Mar 2008]
Function:
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Subcellular Location:
Nucleus. Cytoplasm. Cell projection > ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
Tissue Specificity:
Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
Similarity:
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 SH3 domain.
SWISS:
Q9NSI8
Gene ID:
12892
Database links:
Entrez Gene: 418470 Chicken
Entrez Gene: 12892 Human
Entrez Gene: 67742 Mouse
Entrez Gene: 170637 Rat
NCBI: 48762709 Human
Omim: 607978 Human
SwissProt: Q9NSI8 Human
SwissProt: P57725 Mouse
Unigene: 473341 Human
Unigene: 719474 Human
Unigene: 131406 Mouse
Unigene: 81187 Rat
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