Microtubules are components of the actin cytoskeleton that play crucial roles in cell morphogenesis, cell motility, spindle formation and chromosome movements. Echinoderm microtubule-associated (EML) proteins function to modify the assembly dynamics of microtubules. EML2 (echinoderm microtubule associated protein like 2), also known as ELP70, EMAP2 or EMAPL2, is a cytoplasmic protein that acts to elongate microtubules, while at the same time making them more dynamic. Like other members of the EML family, EML2 contains a hydrophobic ELP (HELP) domain and a large WD repeat domain, both of which allow EML2 to participate in cytoskeleton assembly.
Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Subcellular Location:
Cytoplasm; cytoskeleton.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the WD repeat EMAP family.
Contains 11 WD repeats.
SWISS:
O95834
Gene ID:
24139
Database links:
Entrez Gene: 24139 Human
Entrez Gene: 72205 Mouse
Entrez Gene: 19272 Rat
SwissProt: O95834 Human
SwissProt: Q7TNG5 Mouse
SwissProt: Q6P6T4 Rat
Unigene: 24178 Human
Unigene: 154121 Mouse
Unigene: 76362 Rat
|
|
