Rabbit Anti-SAPS1 antibody | Sunlong Medical

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PP6R1; Protein phosphatase 6, regulatory subunit 1; SAP190; SAPS domain family, member 1.

Cat:

SL19388R

Species Reactivity：

Human,Mouse,Rat,(predicted: Dog,Pig,Cow,Horse,Rabbit,Rhesus monkey, Gorilla, Orangutan)

Immunogen：

KLH conjugated synthetic peptide derived from human SAPS1:31-130/881

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Lane 1: Stomach (Mouse) Lysate at 40 ugLane 2: Testis (Mouse) Lysate at 40 ugLane 3: Lymph node (Mouse) Lysate at 40 ugLane 4: Testis (Rat) Lysate at 40 ugLane 5: HL60 (Human) Cell Lysate at 30 ugLane 6: 293T (Human) Cell Lysate at 30 ugLane 7: Molt-4 (Human) Cell Lysate at 30 ugPrimary: Anti-SAPS1 (SL19388R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 120 kDObserved band size: 120 kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

Subunit:
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Ubiquitous with higher expression in testis.

Similarity:
Belongs to the SAPS family.

SWISS:
Q9UPN7

Gene ID:
22870

Database links:

Entrez Gene: 22870 Human

Omim: 610875 Human

SwissProt: Q9UPN7 Human

Picture

Sample:
Lane 1: Stomach (Mouse) Lysate at 40 ug
Lane 2: Testis (Mouse) Lysate at 40 ug
Lane 3: Lymph node (Mouse) Lysate at 40 ug
Lane 4: Testis (Rat) Lysate at 40 ug
Lane 5: HL60 (Human) Cell Lysate at 30 ug
Lane 6: 293T (Human) Cell Lysate at 30 ug
Lane 7: Molt-4 (Human) Cell Lysate at 30 ug
Primary: Anti-SAPS1 (SL19388R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 120 kD
Observed band size: 120 kD

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