This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]
Function:
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
Post-translational modifications:
Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
Similarity:
Contains 1 CBM21 (carbohydrate binding type-21) domain.
SWISS:
Q9UQK1
Gene ID:
5507
Database links:
Entrez Gene: 5507 Human
Entrez Gene: 53412 Mouse
Omim: 602999 Human
SwissProt: Q9UQK1 Human
SwissProt: Q7TMB3 Mouse
Unigene: 303090 Human
Unigene: 24724 Mouse
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