This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Subunit:
Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
Similarity:
Belongs to the ribose-phosphate pyrophosphokinase family.
SWISS:
P11908
Gene ID:
5634
Database links:
Entrez Gene: 5634 Human
Entrez Gene: 110639 Mouse
Entrez Gene: 24689 Rat
Omim: 311860 Human
SwissProt: P11908 Human
SwissProt: Q9CS42 Mouse
SwissProt: P09330 Rat
Unigene: 654581 Human
Unigene: 272955 Mouse
Unigene: 1164 Rat
Unigene: 163618 Rat
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