This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The SLCterminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in the spinal cord.
Post-translational modifications:
Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
Similarity:
Contains 1 Gla (gamma-carboxy-glutamate) domain.
SWISS:
O14668
Gene ID:
5638
Database links:
Entrez Gene: 785916 Cow
Entrez Gene: 5638 Human
Entrez Gene: 546336 Mouse
Entrez Gene: 363472 Rat
Omim: 604428 Human
SwissProt: A7Z070 Cow
SwissProt: O14668 Human
Unigene: 190341 Human
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