The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Function:
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
Subcellular Location:
Nucleus.
Tissue Specificity:
In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.
Similarity:
Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
Q99811
Gene ID:
51450
Database links:
Entrez Gene: 51450 Human
Entrez Gene: 20204 Mouse
Entrez Gene: 113931 Rat
Omim: 604675 Human
SwissProt: Q99811 Human
SwissProt: Q06348 Mouse
Unigene: 660115 Human
Unigene: 362 Mouse
Unigene: 93004 Rat
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