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Rabbit Anti-PRSS16 antibody
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Protease that may play a role in T-cell development.
Subcellular Location:
Cytoplasmic vesicle. Vesicular, either lysosomal or endosomal.
Tissue Specificity:
Expressed predominantly in cortical thymic epithelial cells.
Similarity:
Belongs to the peptidase S28 family.
SWISS:
Q9NQE7
Gene ID:
10279
Database links:
Entrez Gene: 10279 Human
Entrez Gene: 54373 Mouse
Entrez Gene: 364719 Rat
Omim: 607169 Human
SwissProt: Q9NQE7 Human
SwissProt: Q9QXE5 Mouse
SwissProt: Q3MHS0 Rat
Unigene: 27887 Human
Unigene: 6443 Mouse
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