The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a SLCterminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]
Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed predominantly in peripheral blood leukocytes.
Similarity:
Contains 1 PH domain.
Contains 1 SEC7 domain.
SWISS:
Q9UIA0
Gene ID:
27128
Database links:
Entrez Gene: 27128 Human
Omim: 606514 Human
SwissProt: Q9UIA0 Human
Unigene: 170944 Human
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