The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. [provided by RefSeq, Jul 2008]
Function:
Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
Subunit:
Homodimer.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 1 NTF2 domain.
SWISS:
P61970
Gene ID:
10204
Database links:
Entrez Gene: 10204 Human
Entrez Gene: 621832 Mouse
Entrez Gene: 13651 Mouse
Entrez Gene: 291981 Rat
Omim: 605813 Human
SwissProt: P61970 Human
SwissProt: P61971 Mouse
SwissProt: P61972 Rat
Unigene: 356630 Human
Unigene: 107196 Rat
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