The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Function:
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in heart and lowest levels in lung and liver.
Similarity:
Belongs to the Nth/MutY family.
SWISS:
P78549
Gene ID:
4913
Database links:
Entrez Gene: 4913 Human
Entrez Gene: 18207 Mouse
Entrez Gene: 29541 Rat
Omim: 602656 Human
SwissProt: P78549 Human
SwissProt: O35196 Mouse
Unigene: 66196 Human
Unigene: 148315 Mouse
Unigene: 14632 Rat
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