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Rabbit Anti-Nfe2l3 antibody
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Function:
Activates erythroid-specific, globin gene expression.
Subunit:
Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
SWISS:
Q9Y4A8
Gene ID:
9603
Database links:
Entrez Gene: 9603 Human
Omim: 604135 Human
SwissProt: Q9Y4A8 Human
Unigene: 404741 Human
Unigene: 712898 Human
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