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Rabbit Anti-phospho-Nucleolin (Thr76) antibody
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Function:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Subcellular Location:
Nucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Post-translational modifications:
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
Similarity:
Contains 4 RRM (RNA recognition motif) domains.
SWISS:
P19338
Gene ID:
4691
Database links:
Entrez Gene: 4691 Human
Entrez Gene: 17975 Mouse
Entrez Gene: 25135 Rat
Omim: 112835 Human
SwissProt: P19338 Human
SwissProt: P09405 Mouse
SwissProt: P13383 Rat
Unigene: 79110 Human
Unigene: 154378 Mouse
Unigene: 474153 Mouse
Unigene: 144561 Rat
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