NUDT10 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.
Similarity:
Belongs to the Nudix hydrolase family. DIPP subfamily.
Contains 1 nudix hydrolase domain.
SWISS:
Q8NFP7
Gene ID:
170685
Database links:
Entrez Gene: 170685 Human
Entrez Gene: 616931 Cow
Entrez Gene: 102954 Mouse
Entrez Gene: 58242 Mouse
Entrez Gene: 367747 Rat
Omim: 300527 Human
SwissProt: Q58CW0 Cow
SwissProt: Q8NFP7 Human
SwissProt: P0C027 Mouse
Unigene: 375178 Human
Unigene: 41198 Mouse
Unigene: 426101 Mouse
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