This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
Function:
Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity.
Tissue Specificity:
Widely expressed. Most abundant in liver.
Similarity:
Belongs to the Nudix hydrolase family.
Contains 1 nudix hydrolase domain.
SWISS:
Q9UKK9
Gene ID:
11164
Database links:
Entrez Gene: 11164 Human
Entrez Gene: 53893 Mouse
Entrez Gene: 361274 Rat
Omim: 609230 Human
SwissProt: Q9UKK9 Human
SwissProt: Q9JKX6 Mouse
SwissProt: Q6AY63 Rat
Unigene: 555956 Human
Unigene: 251904 Mouse
Unigene: 55388 Rat
|
|
