Home
>
Product
>
Antibody
>
Rabbit Anti-NUP133 antibody
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Subcellular Location:
Nucleus > nuclear pore complex. Chromosome > centromere > kinetochore. Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.
Tissue Specificity:
Involved in poly(A)+ RNA transport.
Similarity:
Belongs to the nucleoporin Nup133 family.
SWISS:
Q8WUM0
Gene ID:
55746
Database links:
Entrez Gene: 55746 Human
Omim: 607613 Human
SwissProt: Q8WUM0 Human
Unigene: 12457 Human
|
|