This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]
Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.
Subcellular Location:
Nucleus > nuclear pore complex. Nucleus membrane. Tightly associated with the nuclear membrane and lamina.
Similarity:
Belongs to the Nup53 family.
Contains 1 RRM Nup35-type domain.
SWISS:
Q8NFH5
Gene ID:
129401
Database links:
Entrez Gene: 129401 Human
Entrez Gene: 511248 Cow
Entrez Gene: 478830 Dog
Entrez Gene: 100054143 Horse
Entrez Gene: 69482 Mouse
Entrez Gene: 295692 Rat
Entrez Gene: 337461 Zebrafish
Omim: 608140 Human
SwissProt: Q8NFH5 Human
SwissProt: Q8R4R6 Mouse
SwissProt: Q68FY1 Rat
SwissProt: Q6P6X9 Zebrafish
Unigene: 36591 Human
Unigene: 29200 Mouse
Unigene: 203627 Rat
Unigene: 5851 Zebrafish
|
|
