NUPL2 is required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HISLV1, it may participate in the docking of viral Vpr at the nuclear envelope.
Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HISLV1, it may participate in the docking of viral Vpr at the nuclear envelope.
Subunit:
Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro. Interacts with the HISLV1 virus proteins Rev and Vpr. The interaction with HISLV1 Rev, a protein that mediates nuclear export of unspliced viral RNAs, suggests that its function may be bypassed by the HISLV1 virus.
Subcellular Location:
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note: Excluded from the nucleolus.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
O-glycosylated.
Similarity:
Contains 1 C3H1-type zinc finger.
SWISS:
O15504
Gene ID:
11097
Database links:
Entrez Gene: 11097 Human
Entrez Gene: 231042 Mouse
Entrez Gene: 499974 Rat
SwissProt: O15504 Human
SwissProt: Q8CIC2 Mouse
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